The physiology of digestion, and the two herb actions — carminative and bitter — that have real mechanisms behind them.
The physiology, plainly. Digestion is mechanical and enzymatic. The stomach acidifies and begins protein breakdown; the small intestine absorbs, with the pancreas and liver supplying enzymes and bile; the colon absorbs water and hosts the microbiome. Motility is the variable that matters most for common complaints — too fast gives urgency and diarrhoea, too slow gives bloating and constipation, and uncoordinated gives cramping and IBS.
The two herb actions with real mechanisms.
Carminatives — fennel, peppermint, chamomile, ginger — relax smooth muscle in the gut wall, which relieves spasm and helps trapped gas move. This is a plausible, demonstrable mechanism, and it is why carminative herbs are the ones with actual trial evidence for bloating and spasm.
Bitters — dandelion root, gentian, artichoke — stimulate taste receptors that trigger a reflex increase in digestive secretions, including stomach acid and bile. This is a genuine physiological reflex, not folklore, and it is the reason bitters must be tasted to work: a bitter in a capsule bypasses the receptor.
Where the evidence actually sits. Peppermint oil has meta-analytic support for IBS, and the enteric coating is what makes it work in the gut rather than the oesophagus. Psyllium has trial evidence for constipation. Fennel has trial evidence in dyspepsia and infant colic. Everything sold for "detox" and most of what is sold for bloating has none.
The red flags for this system are the point of the month. Difficulty swallowing, vomiting blood, black stool, unexplained weight loss, a new change in bowel habit over 40, or anaemia are all reasons to stop treating a gut problem at home.
Meta-Analysis2023Digestive diseases (Basel, Switzerland)
Menthacarin, a Proprietary Peppermint Oil and Caraway Oil Combination, Improves Multiple Complaints in Patients with Functional Gastrointestinal Disorders: A Systematic Review and Meta-Analysis.
Menthacarin was shown to be effective and safe for the treatment of FD and represents a promising option for symptoms of IBS.
PubMed 36502789 ↗
Meta-Analysis2022Alimentary pharmacology & therapeutics
Systematic review and meta-analysis: efficacy of peppermint oil in irritable bowel syndrome.
Peppermint oil was superior to placebo for the treatment of IBS, but adverse events were more frequent, and quality of evidence was very low.
PubMed 35942669 ↗
Meta-Analysis2018The Cochrane database of systematic reviews
Dietary modifications for infantile colic.
Currently, evidence of the effectiveness of dietary modifications for the treatment of infantile colic is sparse and at significant risk of bias.
PubMed 30306546 ↗
Meta-Analysis2014Journal of clinical gastroenterology
Peppermint oil for the treatment of irritable bowel syndrome: a systematic review and meta-analysis.
Future studies should assess the long-term efficacy and safety of peppermint oil and its efficacy relative to other IBS treatments including antidepressants and antispasmodic drugs.
PubMed 24100754 ↗
Meta-Analysis2010European journal of gastroenterology & hepatology
Therapy options in irritable bowel syndrome.
Evidence-based therapy in IBS provides a number of effective treatment options beyond the fact that many novel compounds under development have failed to reach the market.
PubMed 21389791 ↗
Meta-Analysis1998The American journal of gastroenterology
Peppermint oil for irritable bowel syndrome: a critical review and metaanalysis.
The role of peppermint oil in the symptomatic treatment of IBS has so far not been established beyond reasonable doubt.
PubMed 9672344 ↗