Almost no plant has safety data in pregnancy. That is the finding, not a gap in the search.
The safety of a herb in pregnancy is unknown in almost every case,
because pregnant people are excluded from trials as a matter of course. "Traditional use
in pregnancy" is a claim about history, not about safety, and several plants traditionally
used in pregnancy are now recognised as abortifacient, teratogenic, or both.
Plants to avoid in pregnancy by default, because each has a documented mechanism:
pennyroyal (pulegone, hepatotoxic and abortifacient), rue, tansy, wormwood, Aristolochia,
aloe latex and other stimulant laxatives, comfrey and other pyrrolizidine-containing
plants, goldenseal and barberry (berberine), licorice in quantity, and the essential oils
that are not used in pregnancy — among them pennyroyal, tansy, sage, rosemary in quantity,
and juniper.
The ordinary remedies that are reasonable for ordinary complaints. Ginger has trial
evidence for nausea of pregnancy and is the usual first choice. Soluble fibre and adequate
fluid for constipation. Nettle or ginger tea for a cold. Warm salt-water gargles for a sore
throat. This is a short list because the safe list genuinely is short.
Breastfeeding is a different question with the same shortage of data. Fenugreek and milk
thistle are the two most used galactagogues and both have trial literature of low quality;
where a review found an effect it was small and confidence was low. Anything that
suppresses prolactin or is a dopamine agonist — and that includes large doses of some
common herbs — reduces supply, and none of it should be used to self-manage a real or
perceived low supply without a lactation consultant or clinician, because the commonest
cause is latch and positioning, which no tea fixes.
Meta-Analysis2020The Cochrane database of systematic reviews
Oral galactagogues (natural therapies or drugs) for increasing breast milk production in mothers of non-hospitalised term infants.
Due to extremely limited, very low certainty evidence, we do not know whether galactagogues have any effect on proportion of mothers who continued breastfeeding at 3, 4 and 6 months.
PubMed 32421208 ↗
Meta-Analysis2012The Cochrane database of systematic reviews
Chinese herbal medicine for endometriosis.
Post-surgical administration of CHM may have comparable benefits to gestrinone but with fewer side effects.
PubMed 22592712 ↗
Meta-Analysis2009The Cochrane database of systematic reviews
Chinese herbal medicine for endometriosis.
Post-surgical administration of CHM may have comparable benefits to gestrinone but with fewer side effects.
PubMed 19588398 ↗
Systematic Review2026European journal of clinical nutrition
Herbal galactagogues to improve breastmilk production and lactation in mothers of preterm babies: a systematic review of clinical trials.
There is low certainty evidence that Barley malt with lemon balm, silymarin phytosomes with Galega, Pimpinella anisum seed tea, Moringa oleifera leaf capsules and Latuca sativa (lettuce) syrup increase breastmilk production.
PubMed 41350450 ↗
Systematic Review2021BMC complementary medicine and therapies
Biophysical effects, safety and efficacy of raspberry leaf use in pregnancy: a systematic integrative review.
Many women use raspberry leaf in pregnancy to facilitate labour and birth.
PubMed 33563275 ↗